Hematopoiesis & Immunity
Our laboratory is interested in the development of the blood-forming, or hematopoietic, system in the vertebrate embryo. Most of our studies are aimed at understanding how the hematolymphoid system arises in the zebrafish embryo from the first hematopoietic stem cells. We are utilizing the many advantages that the zebrafish system offers to study the ontogeny of hematopoiesis and immunity. These include the easy visualization of blood cells in the translucent embryo and the ability to dissect genetically the pathways important for blood cell specification, maintenance and function.
- T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation
- A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche
- Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation
- Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy
- Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence
- Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency
- The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney
- Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B
- Notch signaling enhances bone regeneration in the zebrafish mandible
- Endothelial struts enable the generation of large lumenized blood vessels de novo
