Hematopoiesis & Immunity
Our laboratory is interested in the development of the blood-forming, or hematopoietic, system in the vertebrate embryo. Most of our studies are aimed at understanding how the hematolymphoid system arises in the zebrafish embryo from the first hematopoietic stem cells. We are utilizing the many advantages that the zebrafish system offers to study the ontogeny of hematopoiesis and immunity. These include the easy visualization of blood cells in the translucent embryo and the ability to dissect genetically the pathways important for blood cell specification, maintenance and function.
- Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence
- Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency
- The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney
- Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B
- Notch signaling enhances bone regeneration in the zebrafish mandible
- Endothelial struts enable the generation of large lumenized blood vessels de novo
- A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation
- Zebrafish Kit ligands cooperate with erythropoietin to promote erythroid cell expansion
- Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h
- Impact of COVID-19 on early career scientists: an optimistic guide for the future


